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Immunogen

The epitope recognized by PLA0251 maps to a region between residue 50 and 100 of human MAP/ERK kinase kinase 1 using the numbering given in entry NP_005912.1 (GeneID 4214).

Other Notes

MEK (MAPK/ERK kinase) kinase 1 (MEKK1) is encoded by the MAP3K1 (mitogen-activated protein kinase kinase kinase 1) gene. MEKK1 is a component of a protein kinase signal transduction cascade that activates the ERK and JNK kinase pathways by phosphorylation of MEK1 (MAP2K1) and MEK4 (MAP2K4). MEKK1 activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13233].

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide